Antifungal agent 2

Antifungal agent 2 is a broad-spectrum inhibitor effective against Cryptococcus, Candida, and Aspergillus species, inhibiting growth at concentrations as low as 0.5 μg mL.

Antifungal agent 20 demonstrates significant antifungal efficacy against a range of fungal pathogens including Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum.

Antifungal agent 27 (compound 7) is a chemical compound with antifungal properties, exhibiting moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibitory concentration (MIC) values of 8 and 32 μg mL, respectively [1].

Antifungal agent 28 (compound 18) is a selective and potent antifungal agent that disrupts mature Candida biofilms and inhibits pathogenic strains of Candida albicans and non-Candida albicans, including fluconazole-resistant strains.

Antifungal agent 24 (Compound 6) is an antifungal agent that inhibits Candida albicans [MIC: 0.03 μg ml].

Antifungal agent 22 (compound D16) is an orally active antifungal agent with an IC50 of 0.5 μg mL, exhibiting blood-brain barrier permeability, good metabolic stability, and low cytotoxicity. It selectively targets C. neoformans H99 cells by disrupting the integrity of the fungal cell membrane.

Antifungal agent 25 is an effective, broad-spectrum, metabolically stable antifungal agent in vivo. antifungal agent 25 exhibits antifungal effects against both Candida albicans and fluconazole-resistant Candida albicans.

Antifungal Agent 21 presents as a promising candidate within the development of novel agrochemical antifungal agents.

Antifungal Agent 29 (compound 9d) is a potent, selective, and non-toxic agent effective against Cryptococcus neoformans, exhibiting an MIC of ≤0.23 μM [1].

Pradimicin A derivative 26 exhibits antifungal, antiviral, and antiparasitic properties by attaching to d-mannose (Man)-rich glycans in pathogenic organisms [1].

1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, with a minimum inhibitory concentration (MIC) value of 125 ug mL. 4. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.5. Octyl Gallate is a potential anticancer agent, it exhibited decreased MCF-7 & MDA-MB-231 survival and induced apoptosis, with IC50 value of 40 uM. 6. Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) has antiviral activity, it shows an inhibitory effect on the growth of herpes simplex virus type 1 (HSV-1) in HEp-2 or Vero cells. 7. Octyl gallate shows antifungal activity against Saccharomyces cerevisiae ATCC7754 and Zygosaccharomyces bailii ATCC 60483.

Coniferaldehyde (Ferulaldehyde) is a member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as an antifungal agent and a plant metabolite. It is a member of cinnamaldehydes, a phenylpropanoid and a member of guaiacols. It derives from a cinnamaldehyde.

CYP51-IN-2 (compound 1b), a Fluconazole analog, serves as a potent antifungal agent. It exhibits activity against Gypseum and Candida Albicans that is 64 and 128 times higher, respectively, compared to Fluconazole.

Pterophyllin 2 is an agent of natural antifungal. It also against postharvest fruit pathogenic fungi.

1. Santalol has good antibacterial, anti-oxidation and anti-tumor activities. 2. α-Santalol is a potent antimitotic agent induced by interference with microtubule assembly. 3. α-Santalol shows a significant antifungal effect against a dermatophytic fungus

L-Diguluronic acid, a linear polysaccharide copolymer consisting of two L-guluronic acid (G) units, serves as a precursor for Alginate[1], a categorically unbranched polyanionic polysaccharide. Alginate finds application in the development of antifungal agent delivery carriers[2].

'N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is an Ole1p desaturase inhibitor and antifungal agent [1].

(Z)-Lanoconazole is the Z configuration of Lanoconazole, used for investigating dermatophytosis and onychomycosis. It inhibits sterol 14-alpha demethylase, disrupting fungal membrane ergosterol biosynthesis. Lanoconazole is a potent, orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2].

Antifungal Agent 57 (Compound A19) demonstrates potent efficacy against Fluconazole-resistant strains, outperforming Miconazole. It effectively inhibits Candida albicans strains, exhibiting minimum inhibitory concentrations (MIC) ranging from 0.5 to 2 μg mL [1].

(-)-Verazine is an antifungal agent isolated from the dried roots and rhizome of Veratrum maackii Regel, which induces DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. It has applications in research related to fungal infections and neurological diseases [1] [2].

CYP51 PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51 PD-L1, with IC50 values of 0.17 and 0.021 μM, respectively. It shows significant antifungal efficacy and combats drug-resistant fungal strains in vitro, making it valuable for fungal infection research [1].

Antifungal agent 60 (compound 16), a broad-spectrum ergosterol biosynthesis inhibitor, demonstrates potent activity against seven human pathogenic fungal species, including two fluconazole-resistant C. albicans isolates and two multi-drug resistant Candida auris isolates.

Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent

Antifungal agent 6 shows antifungal activity.